Let me recommend Codeweavers’ CrossOver, a commercial implementation of WINE that works on Linux & Mac OS X. It’s reasonably priced, & it makes setting up & configuring both WINE and the programs that run inside WINE much easier. Plus, the company is made up of good people, & they’re very upfront on their site about what works with WINE, what mostly works, what kinda works, & what doesn’t work at all.
http://www.codeweavers.com/